University of California-Davis · BiologyMetabolic Microbiome Lab
Yu-Jui Yvonne Wan · Davis, California
Research Focus
Dr. Yu-Jui Yvonne Wan's lab at UC Davis focuses on creating and testing a novel nanodrug aimed at improving metabolic health and preventing related cancers like liver and colorectal cancer. The lab studies how changes in gut bacteria affect the development of metabolic diseases and aims to design drugs that can effectively target these alterations. Their innovative approaches include developing compounds that can deliver specific biological signals to help combat conditions like insulin resistance and fatty liver disease.
nanodrugmetabolic diseasesgut microbiomeliver cancercolorectal cancerepigeneticsHDAC inhibitorsshort-chain fatty acidsoral therapy
Research Aims
5AIM 01Develop a novel nanodrug to improve metabolic health.
AIM 02Characterize the metabolic effects of the nanodrug in mouse models.
AIM 03Investigate the interaction between gut bacteria and metabolic diseases.
AIM 04Analyze the drug's effectiveness in preventing liver cancer.
AIM 05Determine the mechanisms of action of the nanodrug through gene expression studies.
Skills the Lab Values
cell cultureanimal modelsnanoparticle synthesisdrug formulationbioinformaticstranscriptomic profilingmicroscopyflow cytometryWestern blot
Output against the department
Publications241top 25% of dept.260th of 1,033
this lab
most publishedleast published
Citations8.6ktop 44% of dept.457th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.