AECAlbert Einstein College of Medicine · Biology
Sperm Chromatin Dynamics Unit
Dmitry V Fyodorov · Bronx, New York
Research Focus
Dr. Dmitry Fyodorov's lab at Albert Einstein College of Medicine focuses on understanding how sperm chromatin is structured and remodeled during the development of sperm and the process of fertilization. By studying the unique features of sperm chromatin—especially how it differs from chromatin in other cell types—his team aims to uncover mechanisms that may inform treatments for fertility issues and develop new contraceptives. The research combines molecular biology, biophysics, and genetics using the fruit fly as a model organism.
sperm chromatinspermiogenesisfertilizationchromatin remodelingDrosophilainfertilitycontraceptive drugsThioredoxin systemprotaminechromatin structure
Research Aims
5AIM 01Analyze sperm chromatin structure in Drosophila
AIM 02Investigate factors that mediate chromatin assembly and remodeling
AIM 03Evaluate small-molecule inhibitors of the thioredoxin system
AIM 04Study the relationship between chromatin structure and fertility
AIM 05Explore the role of chromatin in genome integrity and cellular functions.
Skills the Lab Values
chromatin analysisbiochemical assaysbiophysical characterizationin vitro reconstitutionmolecular cloninggenetic manipulation in Drosophilaprotein purificationmicroscopyRNA extractionstructural biology techniques
Output against the department
Publications48bottom 11% of dept.921st of 1,033
this lab
most publishedleast published
Citations5.3kbottom 39% of dept.626th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.