Yale University · BiologyHematopoietic Development Unit
Diane S Krause · New Haven, Connecticut
Research Focus
Dr. Diane Krause's lab at Yale University focuses on understanding how specific blood cell types, like platelets and red blood cells, are formed from stem cells in the bone marrow. By studying a transcription factor called RUNX1, which is commonly mutated in leukemia, the lab aims to uncover the molecular mechanisms that dictate whether a cell becomes a platelet or a red blood cell. This research has important implications for developing new treatments for blood-related diseases.
hematopoiesisRUNX1megakaryocyte-erythroid progenitorsphosphorylationacute myeloid leukemiaproteomicsblood cell differentiationtranscription factorsstem cell biology
Research Aims
4AIM 01Investigate how RUNX1 regulates the fate of megakaryocyte-erythroid progenitors.
AIM 02Determine the role of CDK9 in RUNX1 phosphorylation.
AIM 03Explore how phosphorylated RUNX1 influences cell differentiation.
AIM 04Assess differential levels of RUNX1 proteoforms in blood cell precursors.
Skills the Lab Values
cell and molecular biologyproteomics techniquesFACS sortingATAC-seqRNA analysisWestern blotgene expression assayskinase assayscell culturedata analysis
Output against the department
Publications264top 23% of dept.233rd of 1,033
this lab
most publishedleast published
Citations33ktop 9% of dept.96th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.