University of Pittsburgh-Pittsburgh Campus · Microbiology & ImmunologyCancer Immunology and Metabolism Lab
Greg M. Delgoffe · Pittsburgh, Pennsylvania
Research Focus
Dr. Greg Delgoffe's lab focuses on understanding how the cancer environment affects the immune response, particularly T cells, which are crucial for fighting tumors. They study how factors like low oxygen levels and altered metabolism can change T cell behavior, leading to reduced effectiveness in therapies like immunotherapy. The lab aims to identify new ways to enhance T cell function in the context of cancer treatment, ultimately improving outcomes for patients.
T cell differentiationcancer immunotherapytumor microenvironmentmetabolismT cell exhaustionlactatehypoxiaregulatory T cellsepigeneticsimmune response
Research Aims
5AIM 01Investigate how hypoxia induces epigenetic changes in T cells
AIM 02Assess the impact of hypoxia-reducing treatments on T cell differentiation in melanoma patients
AIM 03Explore how tumor-derived metabolites influence regulatory T cell function
AIM 04Determine the role of lactate metabolism in T cell identity and function
AIM 05Examine mechanisms by which metabolic stress affects immune cell efficacy against cancer.
Skills the Lab Values
cell cultureflow cytometryRNA sequencingmurine modelsgenetic engineeringchromatin analysismetabolic assaysclinical trial designimmunohistochemistrymicroscopy
Output against the department
Publications341top 13% of dept.61st of 486
this lab
most publishedleast published
Citations18ktop 22% of dept.105th of 486
this lab
most citedleast cited
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