UTHThe University of Texas Health Science Center at Houston · Biochemistry
KarmoutyQuintana Lab
Harry Karmouty-Quintana · Houston, Texas
Research Focus
Dr. Harry Karmouty-Quintana's lab at the University of Texas Health Science Center focuses on understanding how ribosome dysfunction contributes to severe lung diseases, particularly interstitial lung disease associated with systemic sclerosis. They investigate how changes in ribosome production affect cell behavior and lead to excessive scarring in the lungs, which can be fatal. The ultimate goal is to uncover new treatment strategies for patients suffering from lung fibrosis.
ribosome biogenesislung fibrosissystemic sclerosisinterstitial lung diseasemyofibroblastsextracellular matrixtranslatomeautoimmune diseasesfibroblaststherapeutic agents
Research Aims
5AIM 01Investigate the role of ribosome biogenesis in lung fibrosis development.
AIM 02Compare the translatome of SSc-ILD fibroblasts with normal fibroblasts.
AIM 03Identify mechanisms leading to increased ribosomal protein production in lung tissues.
AIM 04Evaluate how the altered translatome contributes to fibrotic progression.
AIM 05Develop potential new treatment strategies for interstitial lung diseases.
Skills the Lab Values
PCRcell cultureanimal modelsRNA sequencingWestern blotmicroscopyproteomicsdata analysis using software (e.g. Python)flow cytometryhistology
Output against the department
Publications182top 47% of dept.187th of 402
this lab
most publishedleast published
Citations5.2kbottom 31% of dept.278th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.