Icahn School of Medicine at Mount Sinai · NeuroscienceSchaefer Lab
Anne Schaefer · New York, New York
Research Focus
Dr. Anne Schaefer's lab at the Icahn School of Medicine focuses on understanding how certain brain cells, called microglia, respond to and protect against diseases like Alzheimer's. By investigating the role of specific genes and proteins in microglial behavior, the team aims to reveal new ways to reduce inflammation and enhance the brain's ability to clear harmful substances. Their research could lead to innovative treatments for neurodegenerative diseases.
microgliaAlzheimer's diseasegene expressionneuroprotectioninflammationepigeneticsprotein clearancecell signalingautophagyLYmphocytes
Research Aims
5AIM 01Investigate the role of the transcription factor PU.1 in microglia's response to Alzheimer's disease.
AIM 02Explore the effects of low PU.1 expression on neuroprotection and inflammation.
AIM 03Identify the functions of BRD2 in microglial clearance of amyloid beta.
AIM 04Determine how lymphoid proteins in microglia can suppress inflammation in the brain.
AIM 05Develop new therapeutic strategies targeting microglial functions for neurodegenerative diseases.
Skills the Lab Values
PCRcell culturemouse modelsWestern blotRNA sequencingflow cytometrytranscriptional analysisimmunohistochemistrydata analysisbioinformatics
Output against the department
Publications81bottom 23% of dept.516th of 671
this lab
most publishedleast published
Citations9.5ktop 42% of dept.281st of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.