SLUSaint Louis University · Microbiology & Immunology
Gastric Inflammation Research Lab
Richard J Dipaolo · Saint Louis, Missouri
Research Focus
Dr. Richard J Dipaolo's lab at Saint Louis University focuses on understanding how chronic inflammation in the stomach leads to precancerous conditions and ultimately gastric cancer. The research investigates the roles of specific immune cells and cytokines in the development of gastric metaplasia—a state that increases cancer risk. By using mouse models and human tissue samples, the lab aims to identify potential targets for new preventive and therapeutic strategies against gastric diseases.
inflammationgastric cancerHelicobacter pyloriimmunologymetaplasiacytokinesimmune cellstumorigenesisgastric diseases
Research Aims
5AIM 01Investigate how inflammation contributes to the development of gastric metaplasia.
AIM 02Identify immune cells and cytokines involved in the progression to gastric cancer.
AIM 03Examine the role of Helicobacter pylori in chronic gastritis and tumorigenesis.
AIM 04Develop strategies for early detection of gastric diseases.
AIM 05Explore therapeutic targets for preventing cancer associated with inflammation.
Skills the Lab Values
mouse modelshuman tissue handlingcell cultureimmunohistochemistryRNA analysisflow cytometrycytokine profilingPCRstatistical analysisdata interpretation
Output against the department
Publications140top 46% of dept.224th of 486
this lab
most publishedleast published
Citations4.0kbottom 29% of dept.343rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.