The University of Texas Medical Branch at Galveston · BiochemistrySever Diabetes Lab
Sanja Sever · Galveston, Texas
Research Focus
Dr. Sanja Sever's research focuses on understanding how specific proteins, particularly the proteolytic fragment of the soluble urokinase receptor (suPAR), contribute to kidney disease and diabetes. By studying how this fragment affects both kidney podocytes and pancreatic beta-cells, her lab aims to uncover new therapeutic targets that could help treat chronic kidney disease and Type 1 diabetes. The work is particularly relevant as these conditions are on the rise and can lead to serious health complications.
suPARchronic kidney diseaseinsulin-dependent diabetespodocyte injurypancreatic beta-cells
Research Aims
3AIM 01Investigate the physiological mechanisms by which suPAR D2D3 fragment induces injuries to kidney and pancreas.
AIM 02Examine the effects of D2D3 on actin cytoskeleton and mitochondrial function in podocytes.
AIM 03Explore D2D3's impact on glucose uptake and calcium dynamics in pancreatic beta-cells.
Skills the Lab Values
mouse modelscell culturegene expression analysisWestern blotflow cytometry
Output against the department
Publications94bottom 22% of dept.314th of 402
this lab
most publishedleast published
Citations4.4kbottom 25% of dept.303rd of 402
this lab
most citedleast cited
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