Pennsylvania State University-Main Campus · PhysiologyYengo Lab
Christopher M Yengo · University Park, Pennsylvania
Research Focus
Dr. Christopher Yengo's lab focuses on understanding how specific proteins, known as myosins, influence the shape and function of cells in both the inner ear and heart muscle. By studying myosins that control hair cell structures critical for hearing and those linked to heart conditions, the lab aims to uncover the underlying mechanisms of deafness and heart disease, which could lead to potential therapies.
myosinstereociliahearing losscardiomyopathyactin dynamicsmuscle contractionbiophysicsinner earheart diseasecell biology
Research Aims
3AIM 01Investigate differences between MYO3A and MYO3B motors in shaping stereocilia.
AIM 02Examine the effects of deafness-related mutations on MYO3A function.
AIM 03Study the impact of DCM mutations on cardiac myosin structures and functions.
Skills the Lab Values
cell culturemolecular cloningmicroscopybiochemical assaysFRET analysisoptical trappingelectron microscopydata analysisgenetic engineeringanimal models
Output against the department
Publications154top 49% of dept.139th of 286
this lab
most publishedleast published
Citations3.0kbottom 24% of dept.216th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.