University of Michigan-Ann Arbor · BiologyEpigenetic Metabolism Lab
Sriram Venneti · Ann Arbor, Michigan
Research Focus
Dr. Sriram Venneti's lab focuses on understanding childhood ependymomas, a type of brain tumor that often leads to poor outcomes due to limited treatment options. The research investigates how epigenetic factors and changes in cellular metabolism drive these tumors, aiming to develop effective therapies that target both aspects simultaneously. By exploring the mechanisms behind tumor growth and behavior, the lab seeks to improve prognoses for affected children.
ependyomachildhood cancerepigeneticsmetabolismtherapeutic targets
Research Aims
2AIM 01Elucidate the molecular mechanisms by which EZHIP enhances glycolysis and TCA cycle metabolism.
AIM 02Determine the therapeutic potential of targeting an integrated metabolic/epigenetic pathway to combat these tumors.
Skills the Lab Values
cell cultureChIP-seqmolecular cloningmetabolic assaysWestern blotin vitro assaysglucose metabolism analysisanimal models
Output against the department
Publications366top 14% of dept.141st of 1,033
this lab
most publishedleast published
Citations11ktop 33% of dept.341st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.