RUThe Rockefeller University · Genetics
Immunity Genetics Lab
Jean-Laurent Casanova · New York, New York
Research Focus
Dr. Jean-Laurent Casanova's lab at Rockefeller University focuses on understanding how genetic defects in immune responses can lead to diseases caused by infections, such as chronic mucocutaneous candidiasis and herpes simplex encephalitis. By exploring the genetic basis of these conditions, the lab aims to identify the underlying causes and improve treatment options for affected individuals, particularly in the context of life-threatening COVID-19. The research combines clinical aspects with advanced genomic techniques to shed light on human immunity.
IL-17 immunitychronic mucocutaneous candidiasisherpes simplex encephalitisgeneticsCOVID-19immune disordersinborn errors of immunitymolecular diagnosticsnext-generation sequencingautoantibodies
Research Aims
5AIM 01Investigate the genetic causes of chronic mucocutaneous candidiasis related to IL-17 immunity.
AIM 02Identify new genetic errors linked to herpes simplex encephalitis in children and adults.
AIM 03Explore genetic factors contributing to life-threatening COVID-19 in patients.
AIM 04Develop a better understanding of how mutations affect the immune response to infections.
AIM 05Discover novel therapeutic targets for treating diseases caused by immune deficiencies.
Skills the Lab Values
genome-wide sequencingwhole-exome sequencingRNA sequencingcell cultureflow cytometrybiochemical assaysgenetic analysisimmunological assaysdata analysis with bioinformaticsanimal models
Output against the department
Publications1,388top 1% of dept.3rd of 259
this lab
most publishedleast published
Citations120ktop 3% of dept.9th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.