Columbia University in the City of New York · PhysiologyMuscle Mechanisms Research Lab
Haikel Dridi · New York, New York
Research Focus
Dr. Haikel Dridi's lab at Columbia University focuses on understanding the cellular mechanisms behind skeletal muscle weakness and fatigue, particularly in the context of heart failure. The lab investigates how calcium signaling, specifically through ryanodine receptor type 1 channels, impacts muscle contraction in failing hearts. By studying these mechanisms, the research aims to identify potential therapeutic targets to improve muscle function and quality of life for individuals suffering from heart failure.
heart failuremuscle weaknesscalcium signalingryanodine receptorsoxidative stressmuscle contractionCRISPRproteomicsmass spectrometry
Research Aims
5AIM 01Investigate the role of ryanodine receptor type 1 in muscle contraction abnormalities in heart failure.
AIM 02Identify oxidized cysteine residues in RyR1 channels using advanced mass spectrometry.
AIM 03Explore the interactions of RyR1-associated proteins in normal and pathological conditions.
AIM 04Map changes in the RyR1 microenvironment during heart failure using multiplex quantitative analysis.
AIM 05Develop therapeutic strategies targeting calcium signaling disruptions in heart failure.
Skills the Lab Values
mass spectrometryCRISPR mutagenesismouse modelsprotein labelingelectrophysiologybiochemical assayshigh-resolution structure analysiscryoelectron microscopycell culture
Output against the department
Publications45bottom 5% of dept.271st of 286
this lab
most publishedleast published
Citations1.1kbottom 3% of dept.277th of 286
this lab
most citedleast cited
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