Stanford University · BiologyBeel Lab
Andrew J. Beel · Stanford, California
Research Focus
Dr. Andrew J. Beel's lab at Stanford University focuses on understanding the structure and function of the mitotic chromosome, particularly its central scaffold, which is crucial for proper genetic information dissemination during cell division. The research aims to elucidate the molecular composition and 3D architecture of this scaffold and to develop chemical modulators that could impact cancer cell behavior through scaffold manipulation. This work not only provides fundamental insights into chromosome biology but also has potential implications for cancer therapy.
mitotic chromosomesscaffold structurechromatingenome stabilitycancerpharmacologic modulationchromosome condensationcell divisionchromosomal architecture
Research Aims
3AIM 01Elucidate the molecular composition of the mitotic chromosome scaffold.
AIM 02Determine the three-dimensional architecture of the chromosomal scaffold.
AIM 03Develop chemical modulators to manipulate scaffold assembly.
Skills the Lab Values
cryogenic electron microscopy3D structural analysischromatin imagingnucleolysis techniquesbiochemical assayschemical synthesisprotein purificationcell culturemicroscopy
Output against the department
Publications17bottom 2% of dept.1,013th of 1,033
this lab
most publishedleast published
Citations1.5kbottom 10% of dept.934th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.