University of Maryland, Baltimore · BiochemistryKarbowski Metabolism Lab
Mariusz Karbowski · Baltimore, Maryland
Research Focus
Dr. Mariusz Karbowski's lab at the University of Maryland Baltimore explores how mitochondria and peroxisomes interact at the cellular level, particularly through a specific protein called MARCH5. The research aims to understand the mechanisms of energy metabolism and how these organelles respond to dysfunction. This work is vital for developing new treatments for diseases associated with mitochondrial and peroxisomal malfunctions, especially as the population ages.
mitochondriaperoxisomesubiquitinE3 ligasemetabolismreactive oxygen speciesproteostasisquality controlbiogenesis
Research Aims
5AIM 01Investigate the role of MARCH5 in peroxisomal biogenesis.
AIM 02Determine the specificity of MARCH5 towards mitochondrial and peroxisomal proteins.
AIM 03Understand how MARCH5 activity influences cellular energy balance.
AIM 04Explore the impact of mitochondrial bioenergetics on cell survival and function.
AIM 05Identify potential therapeutic targets for diseases linked to organelle dysfunction.
Skills the Lab Values
biochemical assaysgene editingconfocal microscopyWestern blotcell culturetransfection techniquesprotein purificationRT-qPCRimmunofluorescence
Output against the department
Publications88bottom 20% of dept.321st of 402
this lab
most publishedleast published
Citations13ktop 39% of dept.156th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.