Johns Hopkins University · Neuroscience · PsychologyThe Memory Circuit Lab
James J Knierim · Baltimore, Maryland
Research Focus
Dr. James J. Knierim's lab explores the role of the hippocampus in learning and memory, particularly how its function may change with aging and in conditions like Alzheimer's disease. Using rodent models, the lab studies how different parts of the hippocampus contribute to memory processing and how age-related changes impact cognitive functions. Their research aims to uncover mechanisms underlying memory deficits to help develop potential therapeutic interventions for age-related cognitive decline.
hippocampusmemoryagingAlzheimer's diseasecognitive functionrodentsneural circuitspattern separationepilepsy
Research Aims
5AIM 01Investigate how different parts of the hippocampus are involved in memory processing.
AIM 02Examine the effects of aging on hippocampal functions using rodent models.
AIM 03Identify neurobiological mechanisms related to cognitive preservation and impairment in aging.
AIM 04Explore the impact of heightened neural activity in hippocampal circuits on memory.
AIM 05Develop therapeutic strategies to combat cognitive decline associated with aging.
Skills the Lab Values
animal behavior studiesneuroscience methodselectrophysiologyneuroanatomydata analysisexperimental designrodent modelsimmunohistochemistrybehavioral testing
Output against the department
Publications278top 23% of dept.221st of 965
this lab
most publishedleast published
Citations13ktop 27% of dept.256th of 965
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.