UWMUniversity of Wisconsin-Madison · Biochemistry
Pancreatic Islet Function and Diabetes Group
Alan D Attie · Madison, Wisconsin
Research Focus
Dr. Alan D Attie's research lab focuses on uncovering the genetic and cellular mechanisms behind type 2 diabetes, particularly the roles of pancreatic islet cells in insulin regulation. They use a diverse mouse population to identify new genes and small molecules that influence insulin secretion and ultimately impact blood sugar levels. Their work aims to offer insights into potential therapies to improve pancreatic function and prevent diabetes progression.
type 2 diabetesinsulin secretionpancreatic isletsgenetic screeningsmall molecules
Research Aims
5AIM 01Identify novel genetic regulators of insulin secretion.
AIM 02Explore the role of Zfp148 in pancreatic islet function.
AIM 03Investigate small molecules that mimic genetic modifications in insulin regulation.
AIM 04Integrate mouse and human proteomic data to distinguish diabetic phenotypes.
AIM 05Understand the connections between oxidative stress and pancreatic beta cell dysfunction.
Skills the Lab Values
PCRmouse modelscell cultureproteomicsRNA sequencing
Output against the department
Publications289top 23% of dept.93rd of 402
this lab
most publishedleast published
Citations20ktop 22% of dept.87th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.