Vanderbilt University · BiochemistryOsheroff Antibiotics Lab
Neil Osheroff · Nashville, Tennessee
Research Focus
Dr. Neil Osheroff's lab at Vanderbilt University focuses on understanding how certain antibiotics work and how bacteria resist them. The lab studies key bacterial enzymes that are targets for widely used antibacterial drugs like fluoroquinolones. By investigating these enzymes and their interactions with both existing and novel antibiotics, the team aims to develop new strategies to combat antibiotic-resistant bacterial infections.
antibiotic resistancetopoisomerasegyrasefluoroquinolonesantibacterial agentsDNA breaksbacterial pathogensnovel inhibitors
Research Aims
5AIM 01Investigate the mechanism of action of fluoroquinolone antibiotics.
AIM 02Characterize how bacterial enzymes resist fluoroquinolone action.
AIM 03Identify novel compounds that target bacterial topoisomerases.
AIM 04Study the action of new antibiotic classes against resistant strains.
AIM 05Utilize diverse bacterial systems to assess drug effectiveness.
Skills the Lab Values
cell cultureenzyme activity assaysDNA manipulationMolecular cloning techniquesin vitro studiesbacterial geneticsprotein purificationantibiotic susceptibility testingPCR
Output against the department
Publications303top 20% of dept.82nd of 402
this lab
most publishedleast published
Citations19ktop 22% of dept.90th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.