WMCWeill Medical College of Cornell University · Neuroscience
Tau Pathology and Therapeutics Lab
Li Gan · New York, New York
Research Focus
Dr. Li Gan's lab at Weill Medical College focuses on understanding the mechanisms that lead to Alzheimer's disease and frontotemporal dementia, mainly by studying misfolded tau proteins in human neurons. The lab employs innovative techniques to explore how different proteins and genetic factors influence the development of tau pathology. By investigating these complex interactions, the lab aims to identify potential new treatments for these debilitating diseases.
Alzheimer's diseasetau proteinfrontotemporal dementiaproteomicsstem cellsamyloidtau aggregatesdrug discoverycellular mechanismsgenetic pathways
Research Aims
3AIM 01Identify tau protein interactions influenced by amyloid and tau seeding in human neurons.
AIM 02Examine the role of VPS29 in tau aggregation and its impact on proteomic profiles.
AIM 03Investigate how UFMylation regulates tau aggregation and its potential as a therapeutic target.
Skills the Lab Values
proteomicsCRISPRiPSC culturemass spectrometrycellular modelingtranscriptomicsbioinformaticsdata integrationco-immunoprecipitationdeep learning
Output against the department
Publications324top 21% of dept.138th of 671
this lab
most publishedleast published
Citations19ktop 22% of dept.148th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.