Washington University in St Louis · GeneticsMeers Lab
Michael P Meers · Saint Louis, Missouri
Research Focus
Dr. Michael P. Meers's lab at Washington University focuses on understanding how specific epigenetic changes during early human development can influence the reprogramming of cells into desired types, such as neurons or heart cells. Through innovative time-lapse profiling techniques, the lab aims to uncover the precise molecular events that govern successful cell differentiation, which is vital for advancements in regenerative medicine. Ultimately, this research seeks to create better methods for converting one type of cell into another efficiently and reliably.
epigeneticscell reprogrammingchromatingene regulationregenerative medicinecell differentiationtranscription factorsfibroblaststime-lapse imagingdata standards
Research Aims
5AIM 01Identify epigenetic factors that influence cellular reprogramming efficiency.
AIM 02Develop time-lapse profiling methods for observing chromatin dynamics in single cells.
AIM 03Create standardized datasets for public use to support research and training in deep learning applications.
AIM 04Test the impact of chromatin regulatory domains on reprogramming outcomes using modified Cas9.
AIM 05Improve methods of cell type conversion for therapeutic applications.
Skills the Lab Values
time-lapse epigenome profilingchromatin analysiscell culture techniquesmolecular cloningCRISPR/Cas9 systemsdata analysistranscription factor overexpressionDNA sequencingimmunofluorescenceexperimental design
Output against the department
Publications83bottom 23% of dept.199th of 259
this lab
most publishedleast published
Citations2.6kbottom 13% of dept.225th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.