Harvard University · Microbiology & ImmunologyThe Connectome Project
Jeff W Lichtman · Cambridge, Massachusetts
Research Focus
Dr. Jeff Lichtman's lab focuses on mapping the brain's intricate connections at the level of individual synapses, particularly in the mouse hippocampus, which plays a crucial role in memory and navigation. By using advanced imaging techniques, the lab aims to generate a comprehensive brain map that will enhance our understanding of how brain circuits function and how they may malfunction in diseases like Alzheimer’s. The research also emphasizes involving students in hands-on scientific processes to foster education and discovery.
connectomicsmouse brainsynapse mappinghippocampal circuitselectron microscopybrain disordersneural networksAlzheimer's diseasedata sharingneuroimaging
Research Aims
5AIM 01Generate a synapse-level map of the mouse hippocampus.
AIM 02Develop scalable imaging and processing pipelines for large brain datasets.
AIM 03Integrate structural connectome data with transcriptomic insights.
AIM 04Identify key circuit principles related to memory and spatial cognition.
AIM 05Mentor students in experimental design and data analysis.
Skills the Lab Values
serial-section electron microscopyimage processing3D reconstructionmicroCT scanningion beam millinglight microscopycustom software developmentdata analysisregional connectivity analysisproofreading scientific data
Output against the department
Publications358top 12% of dept.56th of 486
this lab
most publishedleast published
Citations37ktop 7% of dept.34th of 486
this lab
most citedleast cited
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