Wright State University-Main Campus · BiochemistryCho Lipid Lab
Kwangjin Cho · Dayton, Ohio
Research Focus
Dr. Kwangjin Cho's lab at Wright State University focuses on understanding how specific lipids at the Golgi complex influence the composition and organization of the plasma membrane in human cells. By examining the role of phosphatidylinositol 4-phosphate and its impact on membrane protein localization, particularly the KRAS oncogene, the lab aims to uncover new insights into cellular signaling and potential vulnerabilities in cancer pathways. This research is critical for linking cellular metabolism to lipid regulation and offers implications for understanding and treating KRAS-driven cancers.
KRASPhospholipidsGolgi ApparatusLipid MetabolismCell SignalingPhosphatidylinositol 4-phosphateMembrane DynamicsOncogenesisGlucose Metabolism
Research Aims
5AIM 01Investigate how Golgi PI4P acts as a spatial organizer of the inner plasma membrane.
AIM 02Determine the role of glucose in maintaining Golgi PI4P levels through protein glycosylation.
AIM 03Examine the impact of lipid composition on KRAS membrane interactions and signaling.
AIM 04Explore the mechanisms regulating phosphatidylserine transport and localization.
AIM 05Understand the relationship between glucose metabolism and Golgi PI4P regulation.
Skills the Lab Values
Cell CultureMicroscopysiRNA ScreeningHigh-Content ImagingBiochemical AssaysProtein Glycosylation AnalysisMolecular CloningLipid Metabolism TechniquesData Analysis
Output against the department
Publications20bottom 1% of dept.399th of 402
this lab
most publishedleast published
Citations1.3kbottom 5% of dept.382nd of 402
this lab
most citedleast cited
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