University of North Carolina at Chapel Hill · GeneticsCell Cycle and Cancer Resistance Lab
Jeremy Purvis · Chapel Hill, North Carolina
Research Focus
Dr. Jeremy Purvis’s lab focuses on understanding the cell cycle and its role in cancer treatment resistance, especially in breast cancer. They use innovative computational models and experimental techniques to explore how tumor cells survive and evade therapies like CDK4/6 inhibitors. The lab aims to identify the molecular mechanisms behind drug resistance and how the cell cycle adapts under different conditions, potentially leading to better cancer therapies.
cell cycledrug resistancebreast cancercomputational modelingsingle-cell analysistherapeutic responsecellular plasticityproteomicscancer mechanisms
Research Aims
5AIM 01Identify mechanisms of drug resistance in breast cancer cells.
AIM 02Develop computational models to understand cell cycle behavior.
AIM 03Examine cell cycle plasticity during stem cell differentiation.
AIM 04Investigate non-cell-autonomous signaling effects on the cell cycle.
AIM 05Discover new biomarkers for targeted cancer therapies.
Skills the Lab Values
single-cell RNA sequencingdeep quantitative proteomicsmultiplexed imagingstochastic modelingtime-lapse microscopymass spectrometrydata analysis in Rcell culture techniquesstatistical modeling using SPCA
Output against the department
Publications139bottom 45% of dept.143rd of 259
this lab
most publishedleast published
Citations4.1kbottom 21% of dept.205th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.