New York University · Microbiology & ImmunologyAlphavirus Pathogenesis Lab
Kenneth Stapleford · New York, New York
Research Focus
Dr. Kenneth Stapleford's lab investigates how certain viruses, particularly alphaviruses like Chikungunya, infect humans and spread through insect vectors. By studying the molecular mechanisms behind these processes, his team aims to reveal how viral proteins adapt to different hosts and environments. This research can inform efforts to combat viral diseases and improve public health.
alphavirusesChikungunya virusviral transmissioninsect vectorsviral pathogenesisglycoprotein adaptationarboviral diseasedeep sequencingpublic healthviral infectivity
Research Aims
5AIM 01Investigate the mechanisms of CHIKV structural proteins in promoting viral entry and pathogenesis.
AIM 02Understand how temperature influences CHIKV adaptation in mosquito vectors.
AIM 03Examine the role of host lipids in viral transmission and adaptation.
AIM 04Identify genetic interactions between CHIKV proteins in different host environments.
AIM 05Explore the impact of glycoprotein mutations on virus infectivity in insects and mammals.
Skills the Lab Values
viral culturemolecular cloningdeep sequencingin vivo experimentationbiochemical assaysmouse modelsgenetic interaction analysisprotein purificationtemperature sensitivity assaysbioinformatics
Output against the department
Publications87bottom 29% of dept.345th of 486
this lab
most publishedleast published
Citations4.3kbottom 33% of dept.327th of 486
this lab
most citedleast cited
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