UMCUniversity of Massachusetts Chan Medical School · Biology
Lewis Oncology Lab
Brian C Lewis · Worcester, Massachusetts
Research Focus
Dr. Brian C. Lewis's lab at the University of Massachusetts Medical School focuses on understanding and potentially treating pancreatic cancer, a leading cause of cancer deaths. The lab studies how specific signaling pathways, particularly the MTOR pathway, contribute to tumor growth and survival. They utilize advanced mouse models and human cancer cell lines to investigate the effects of inhibiting this pathway, aiming to find new therapeutic strategies for effective treatment.
pancreatic cancerMTOR signalingKRAS mutationstumor progressioncombination therapy
Research Aims
3AIM 01Investigate the impact of genetic inactivation of MTORC2 on established pancreatic cancer progression.
AIM 02Identify gene expression and proteomic changes following MTOR complex inhibition in cancer cell lines.
AIM 03Evaluate the efficacy of novel MTOR inhibitor combination therapies in pancreatic tumor organoids.
Skills the Lab Values
in vivo mouse modelssingle-cell RNA sequencingproteomicsgenetic ablation techniquescell culturedata integrationmolecular biology techniquestherapeutic efficacy testinggene expression analysis
Output against the department
Publications122bottom 44% of dept.583rd of 1,033
this lab
most publishedleast published
Citations5.6kbottom 41% of dept.606th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.