University of California-Irvine · BiologyLyon Lab
David C Lyon · Irvine, California
Research Focus
Dr. David C. Lyon's lab at UC Irvine focuses on advancing treatments for vision loss due to retinal degeneration diseases like age-related macular degeneration and retinitis pigmentosa. The research explores the use of retinal progenitor tissue transplants to restore vision by investigating how these transplants integrate into the visual system and influence higher-level visual processing in the brain. The ultimate aim is to improve vision among patients who have lost significant retinal tissue.
retinal transplantationvision restorationretinal degenerationneurophysiologyvisual processing
Research Aims
3AIM 01Investigate the integration of retinal progenitor sheets into retinal degeneration models.
AIM 02Evaluate the visual responses in the superior colliculus after transplantation.
AIM 03Assess the restoration of complex visual processing in the visual cortex.
Skills the Lab Values
retinal tissue transplantationvisual behavior assessmentgenetically modified animal modelselectrocorticographyneural circuit tracing3D anatomical modelingsurgical techniques in rodentsdata analysis using Pythonhistology techniques
Output against the department
Publications73bottom 21% of dept.819th of 1,033
this lab
most publishedleast published
Citations4.4kbottom 34% of dept.684th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.