UMCUniversity of Massachusetts Chan Medical School · Genetics
Bone Health and Gene Therapy Lab
Jae-Hyuck Shim · Worcester, Massachusetts
Research Focus
Dr. Jae-Hyuck Shim's lab focuses on understanding and treating bone loss diseases, particularly in the context of inflammatory arthritis and osteogenesis imperfecta (a genetic disorder leading to fragile bones). They develop innovative gene therapies using specialized viruses to enhance bone health by targeting specific proteins that regulate bone formation. Through their research, they aim to discover new treatments that could improve patient outcomes in these conditions.
bone lossinflammatory arthritisosteogenesis imperfectagene therapyWNT signalingosteoblastsrecombinant adeno-associated virus (rAAV)Schnurri-3 (SHN3)collagen productionbone regeneration
Research Aims
3AIM 01Promote healing of bone loss in inflammatory arthritis by inhibiting SHN3.
AIM 02Develop long-lasting gene therapies for osteogenesis imperfecta using bone-targeted rAAV.
AIM 03Investigate the molecular mechanisms by which SHN3 deficiency protects against inflammation-induced bone loss.
Skills the Lab Values
PCRcell culturemouse modelsviral vector designgene editingimmunohistochemistrytranscriptomic profilingbone histomorphometrybiomechanical testingorganoid culture
Output against the department
Publications110bottom 34% of dept.172nd of 259
this lab
most publishedleast published
Citations7.4kbottom 41% of dept.152nd of 259
this lab
most citedleast cited
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