University of California-Los Angeles · GeneticsGermline Insight Lab
Paul T. Spellman · Los Angeles, California
Research Focus
Dr. Paul T. Spellman's lab at UCLA focuses on understanding how genetic factors influence the development and aggressiveness of prostate cancer. The lab investigates the role of germline genomic variations in the evolution of prostate cancer, aiming to improve risk assessment and treatment strategies for this common and serious disease. By analyzing large patient cohorts and using advanced bioinformatics methods, they seek to uncover insights that can help predict the risk of aggressive prostate cancer in men.
prostate cancergermline geneticsbioinformaticsGWASclinical risk prediction
Research Aims
3AIM 01Quantify germline-somatic interactions in prostate cancer.
AIM 02Identify ancestry-based germline-somatic interactions.
AIM 03Develop a targeted DNA-sequencing panel for clinical risk prediction.
Skills the Lab Values
transcriptome-wide association studies (TWAS)DNA sequencingbioinformaticscancer cohort analysispathway analysis
Output against the department
Publications460top 15% of dept.38th of 259
this lab
most publishedleast published
Citations151ktop 2% of dept.4th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.