Oregon Health & Science University · NeuroscienceUnni Lab
Vivek Unni · Portland, Oregon
Research Focus
The Unni lab at Oregon Health & Science University focuses on understanding Lewy body dementia, a type of neurodegenerative disease. Their research explores how different protein pathologies, particularly alpha-synuclein and beta-amyloid, interact and spread in the brain, which may help in developing new treatments. The lab uses advanced imaging techniques to study changes in neurons over time and how immune cells contribute to these diseases.
Lewy Body Dementiaalpha-synucleinbeta-amyloidneurodegenerationimmunology
Research Aims
5AIM 01Investigate the role of alpha-synuclein in Lewy body pathology.
AIM 02Explore the interaction between beta-amyloid plaques and alpha-synuclein.
AIM 03Analyze the contributions of microglia in the spread of proteinopathy.
AIM 04Develop new therapeutic strategies targeting protein interactions in dementia.
AIM 05Utilize advanced imaging techniques to study neuronal changes over time.
Skills the Lab Values
multiphoton imagingmouse modelscell cultureimmunohistochemistrygenetic engineering
Output against the department
Publications42bottom 8% of dept.617th of 671
this lab
most publishedleast published
Citations6.5kbottom 45% of dept.372nd of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.