Loyola University Chicago · PhysiologyZima Lab
Aleksey V Zima · Chicago, Illinois
Research Focus
Dr. Aleksey V Zima's lab at Loyola University Chicago focuses on understanding how oxidative stress affects the heart's calcium regulation, particularly through the dysfunction of a key protein called the ryanodine receptor. This research aims to uncover the molecular mechanisms behind cardiac issues, especially during conditions like myocardial infarction, which is critical for developing new therapies that can improve heart health. The lab uses advanced genetic models and pharmacological approaches to explore potential treatments for heart diseases.
calcium regulationoxidative stressryanodine receptormyocardial infarctionarrhythmias
Research Aims
3AIM 01Define the molecular mechanisms of RyR dysfunction induced by intersubunit cross-linking
AIM 02Investigate the role of RyR cross-linking in Ca dysregulation during myocardial infarction
AIM 03Test the efficacy of pharmacological interventions on RyR stabilization during oxidative stress.
Skills the Lab Values
mouse modelstransgenic miceconfocal microscopycryoelectron microscopyechocardiography
Output against the department
Publications129bottom 41% of dept.168th of 286
this lab
most publishedleast published
Citations4.7kbottom 39% of dept.175th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.