Harvard University · Microbiology & ImmunologyGaudet Lab
Rachelle Gaudet · Cambridge, Massachusetts
Research Focus
Dr. Rachelle Gaudet's lab at Harvard University studies membrane proteins, which are crucial for helping cells communicate and transport substances. By using techniques like X-ray crystallography and advanced microscopy, the lab investigates how these proteins work, particularly in bacteria. The research has important implications for drug development and understanding how bacteria adapt to their environments.
membrane proteinsbacterial transportersprotein engineeringbiochemical assaysmolecular dynamicssynthetic biologymetabolic pathwayshost-microbe interactions
Research Aims
5AIM 01Uncover the molecular mechanisms of membrane protein function.
AIM 02Identify metal ion selectivity determinants in Nramp transporters.
AIM 03Explore the structure and function of prodrug-activating peptidases.
AIM 04Elucidate the structural basis of ligand specificity in TM-LuxR regulators.
AIM 05Investigate the evolutionary adaptations of bacterial membrane proteins.
Skills the Lab Values
X-ray crystallographycryogenic electron microscopymolecular dynamics simulationsbioinformaticscell cultureprotein mutational screeningbiochemical assaysdata analysis in R or Python
Output against the department
Publications171top 39% of dept.188th of 486
this lab
most publishedleast published
Citations9.5ktop 38% of dept.185th of 486
this lab
most citedleast cited
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