University of Iowa · PhysiologyFungal Drug Resistance Lab
W Scott Moye-Rowley · Iowa City, Iowa
Research Focus
Dr. W Scott Moye-Rowley's lab at the University of Iowa explores how certain genetic changes in the fungus Aspergillus fumigatus help it resist antifungal drugs. They specifically study a gene called cyp51A, which is critical for drug resistance, and aim to understand how mutations in this gene influence its expression and the fungus's ability to survive drug treatment. The research has significant implications for improving treatment strategies against serious fungal infections.
Aspergillus fumigatusdrug resistancecyp51A geneazoleschromatin accessibilitytranscription factorsmurine modelsATAC-seqgene expression regulationfungal pathogens
Research Aims
5AIM 01Investigate the role of cyp51A mutations in drug resistance in Aspergillus fumigatus.
AIM 02Examine the function of the AtrR transcription factor in cyp51A gene regulation.
AIM 03Evaluate chromatin accessibility changes associated with cyp51A promoter mutations.
AIM 04Utilize murine models to study the azole response in Aspergillus fumigatus infections.
AIM 05Identify proteins that interact with AtrR and their role in chromatin modification.
Skills the Lab Values
PCRgel electrophoresiscell cultureATAC-seqprotein purificationchromatin modification assaysgene cloninganimal modelsgenetic sequencingbiochemical analysis
Output against the department
Publications127bottom 40% of dept.173rd of 286
this lab
most publishedleast published
Citations8.6ktop 40% of dept.113th of 286
this lab
most citedleast cited
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