Boston University · BiologyMoore Lab
Tara L Moore · Boston, Massachusetts
Research Focus
Dr. Tara Moore's lab at Boston University Medical Campus focuses on using extracellular vesicles derived from mesenchymal stem cells to understand and potentially treat age-related cognitive decline and neurodegenerative diseases in primates. The research explores how these vesicles can enhance brain health by improving memory, reducing inflammation, and promoting tissue repair. A key aspect is studying the differences between male and female extracellular vesicles and their impact on brain recovery from injuries and age-related conditions.
extracellular vesiclesneurodegenerationcognitive declinemesenchymal stem cellsneural recoveryinflammationaged primatessex differencesbrain healthproteomics
Research Aims
5AIM 01Investigate the therapeutic effects of MSC-derived extracellular vesicles in treating age-related cognitive decline in primates.
AIM 02Analyze sex differences in the content and efficacy of extracellular vesicles from male and female donors.
AIM 03Explore the mechanisms of action of extracellular vesicles in reducing neuroinflammation after brain injury.
AIM 04Assess the impact of extracellular vesicle treatment on neural plasticity and recovery after cortical injury.
AIM 05Identify biomarkers associated with improved cognitive performance following vesicle treatment.
Skills the Lab Values
cell cultureproteomic profilingin vitro modelsanimal behavioral assaysmagnetic resonance imaging (MRI)immunohistochemistryRNA extractiondata analysishistological techniquessingle-cell transcriptomics
Output against the department
Publications141top 49% of dept.502nd of 1,033
this lab
most publishedleast published
Citations3.7kbottom 28% of dept.740th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.