University of Minnesota-Twin Cities · NeuroscienceTau Innovation Lab
Dezhi Liao · Minneapolis, Minnesota
Research Focus
Dr. Dezhi Liao's lab at the University of Minnesota focuses on understanding how tau proteins misbehave in diseases like Alzheimer's. They explore how modifications to tau proteins impact brain function and contribute to neurodegenerative diseases. By using a novel mouse model and studying mild traumatic brain injury, they aim to identify the mechanisms that lead to tau-related dysfunction, ultimately seeking to develop new therapeutic strategies.
tauopathiesAlzheimer's diseasemild traumatic brain injuryphosphorylationsynaptic dysfunctionneurodegenerationtau proteinsmouse modelsdendritic spinestherapeutic interventions
Research Aims
3AIM 01Investigate how phosphorylation changes the distribution of tau proteins in neurons.
AIM 02Evaluate the effects of phosphorylated tau on synaptic functions and brain circuits.
AIM 03Assess the benefits of inhibiting tau phosphorylation to mitigate its pathological effects.
Skills the Lab Values
mouse modelselectrophysiologycell cultureWestern blotimmunohistochemistrymolecular biology techniquesdrug developmentbiochemical assaysphosphorylation analysisbehavioral assays
Output against the department
Publications39bottom 7% of dept.626th of 671
this lab
most publishedleast published
Citations6.3kbottom 43% of dept.380th of 671
this lab
most citedleast cited
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