RUThe Rockefeller University · Biology
Telomere Research Laboratory
Titia De Lange · New York, New York
Research Focus
Dr. Titia De Lange's lab at Rockefeller University studies how telomeres—the protective caps at the ends of chromosomes—affect cancer and cellular aging. They investigate the mechanisms behind genome instability in tumors caused by telomere shortening, and how this can lead to issues such as replicative senescence, which limits cell proliferation. Their research aims to provide insights that could potentially inform cancer treatments and preventive strategies.
telomeresgenome instabilityDNA repaircancerreplicative senescenceCRISPRtelomerasetumor suppressor pathwayATM signaling
Research Aims
4AIM 01Investigate how telomeres influence tumorigenesis and genome instability.
AIM 02Study the mechanisms of replicative senescence due to telomere shortening.
AIM 03Determine the regulation of telomere length in cells.
AIM 04Test the role of neotelomeres in terminating genome instability cycles.
Skills the Lab Values
cell cultureCRISPR interferenceDNA repair techniquesgenomic sequencingin vitro modelingWestern blotflow cytometrymicroscopyRNA extraction
Output against the department
Publications242top 25% of dept.258th of 1,033
this lab
most publishedleast published
Citations52ktop 5% of dept.49th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.