Midwestern University-Downers Grove · BiologyPrecision Dosing Lab for Antibiotic Resistance
Nathaniel James Rhodes · Downers Grove, Illinois
Research Focus
Dr. Nathaniel James Rhodes leads a research lab focused on the development of Precision Dosing strategies for antibiotic treatment in patients suffering from severe pneumonia caused by antibiotic-resistant bacteria. The lab uses innovative pharmacokinetic (PK) models to optimize beta-lactam antibiotic dosing, aiming to improve patient outcomes and reduce treatment failures. Through this work, the lab addresses critical public health challenges associated with antibiotic resistance.
antibiotic resistancebeta-lactamspharmacokineticssevere pneumoniaPrecision Dosingclinical pharmacodynamicshealthcare outcomesKlebsiella pneumoniaePseudomonas aeruginosaPK/PD modeling
Research Aims
3AIM 01Develop and evaluate pharmacokinetic models for beta-lactam antibiotics in severely ill pneumonia patients.
AIM 02Assess the influence of alveolar beta-lactam pharmacodynamics on treatment outcomes.
AIM 03Identify clinical risk factors for inadequate beta-lactam dosing due to discordance between alveolar and plasma drug concentrations.
Skills the Lab Values
pharmacokinetic modelingclinical researchdata analysispatient sampling proceduresbiostatisticsantibiotic susceptibility testinglaboratory techniques for microbiologyBronchoalveolar lavagestatistical software (such as R or SAS)
Output against the department
Publications172top 38% of dept.396th of 1,033
this lab
most publishedleast published
Citations2.4kbottom 17% of dept.858th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.