University of North Carolina at Chapel Hill · PharmacologyCirculatory Solutions Lab
David S. Lawrence · Chapel Hill, North Carolina
Research Focus
Dr. David S. Lawrence's lab at the University of North Carolina Chapel Hill focuses on developing innovative drug delivery systems to improve treatments for thromboembolism, particularly in cancer patients. The lab's groundbreaking research utilizes a bioengineering approach that combines thrombolytic enzymes with vitamin B12 to create a targeted, effective delivery platform, using the body's circulatory system as a natural reservoir. This technology aims to enhance the safety and efficacy of thrombolytic therapies, especially in high-risk populations like cancer patients and pregnant women.
thrombolyticsdrug deliverybioengineeringcancer therapypulmonary embolismphotothrombolysisbiocompatible systemsprotein-based drugsclinical researchtherapeutic efficacy
Research Aims
5AIM 01Validate the effectiveness of a new drug delivery platform for thrombolytics.
AIM 02Evaluate the multi-drug synergism of thrombolytic therapies.
AIM 03Assess the safety and efficacy of treatments in high-risk patients.
AIM 04Investigate the role of photon-targeted drug release in therapeutic applications.
AIM 05Optimize delivery parameters to maximize therapeutic outcomes.
Skills the Lab Values
cell culturemolecular cloningphotothermal therapyin vivo animal modelsbiochemical assaysdrug efficacy testingfluorescence microscopyprotein characterizationdosimetrydata analysis
Output against the department
Publications263top 31% of dept.143rd of 462
this lab
most publishedleast published
Citations10ktop 37% of dept.171st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.