University of Pennsylvania · BiologyFuchs Immunotherapy Lab
Serge Y Fuchs · Philadelphia, Pennsylvania
Research Focus
Professor Serge Fuchs leads a lab focused on enhancing the effectiveness of CAR T cell therapy for solid tumors in cancer treatment. His research investigates how the tumor microenvironment suppresses CAR T cells and aims to develop strategies to improve their viability and anti-tumor efficacy. The lab employs various molecular techniques to understand these mechanisms and explore new interventions that could make CAR T therapy more successful against challenging cancer types.
CAR T cellstumor microenvironmentcancer immunotherapyimmune suppressionregulatory mechanisms
Research Aims
5AIM 01Investigate the mechanisms by which the tumor microenvironment suppresses CAR T cell function.
AIM 02Identify the roles of specific proteins in CAR T cell inactivation.
AIM 03Explore ways to enhance the viability of CAR T cells in solid tumors.
AIM 04Develop novel CAR T cell constructs that resist immunosuppressive signals.
AIM 05Test combination therapies to improve CAR T cell efficacy against solid tumors.
Skills the Lab Values
cell culturemolecular cloningflow cytometryWestern blottingRNA sequencingprotein assaysin vivo tumor modelsbioinformaticsdata analysisimmunological techniques
Output against the department
Publications274top 21% of dept.222nd of 1,033
this lab
most publishedleast published
Citations14ktop 27% of dept.274th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.