University of Notre Dame · BiologyMycobacterial Pathogenesis Lab
Patricia A Champion · Notre Dame, Indiana
Research Focus
Dr. Patricia A Champion's lab at the University of Notre Dame focuses on understanding how pathogenic mycobacteria, like Mycobacterium tuberculosis, cause diseases in humans. They specifically study the ways in which these bacteria adapt to different pH levels in the body and how that impacts their ability to survive and infect. Through innovative research techniques, the lab aims to uncover new insights into treatment and prevention strategies for mycobacterial infections.
mycobacterial pathogenesisESX-1 secretionpH-dependent switchingMycobacterium tuberculosisinfection mechanisms
Research Aims
3AIM 01Define the genetic requirements for hemolysis at acidic pH.
AIM 02Measure changes in ESX-1 secretion in response to acidic pH.
AIM 03Investigate substrate switching during mycobacterial infection.
Skills the Lab Values
molecular geneticsproteomicscell cultureanimal modelsqRT-PCRimmunoprecipitationlysate assayschemical inhibitiondata analysis
Output against the department
Publications55bottom 13% of dept.894th of 1,033
this lab
most publishedleast published
Citations2.6kbottom 19% of dept.840th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.