Boston University · PharmacologyJiang Lab
Zhen Yue Jiang · Boston, Massachusetts
Research Focus
Dr. Zhen Yue Jiang's lab at Boston University Medical Campus focuses on understanding how neutrophils contribute to vascular aging and related diseases. They explore the role of neutrophil elastase, a key protein involved in inflammation, and how it influences arterial stiffness and cardiovascular health as we age. The research aims to unravel the molecular mechanisms behind these processes and develop potential new treatments to combat age-related vascular issues.
vascular agingneutrophilsinflammationarterial stiffnessneutrophil elastasecardiovascular diseasesfibrosistherapeuticsvascular remodeling
Research Aims
5AIM 01Investigate the role of neutrophil elastase in promoting vascular inflammation and stiffness.
AIM 02Examine the interaction of neutrophils and blood vessels in aging-related vascular damage.
AIM 03Assess the potential therapeutic effects of inhibiting neutrophil elastase in mice.
AIM 04Explore the signaling pathways activated by neutrophil elastase in vascular cells.
AIM 05Study the relationship between obesity, neutrophil activity, and vascular aging.
Skills the Lab Values
mice handlingcell culturePCRWestern blotflow cytometryin vivo studiesin vitro assaysimmunohistochemistrysignal transduction analysis
Output against the department
Publications55bottom 8% of dept.423rd of 462
this lab
most publishedleast published
Citations7.6ktop 48% of dept.220th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.