University of South Carolina-Columbia · BiologyMcCarthy Neurovascular Lab
Cameron Mccarthy · Columbia, South Carolina
Research Focus
Dr. Cameron McCarthy's lab focuses on understanding how diabetes affects the cerebrovascular system, particularly after a stroke. They study the role of a specific protein modification, known as O-GlcNAcylation, which may worsen neurovascular injuries and hinder recovery from stroke in diabetic patients. Their research aims to uncover mechanisms that could lead to new therapeutic targets for improving outcomes in stroke patients with diabetes.
diabetesstrokeneurovascular injuryO-GlcNAcylationcerebrovascular integrityprotein modificationvascular functionhigh-fat dietischemiachronic recovery
Research Aims
5AIM 01Investigate the role of O-GlcNAcylation in stroke susceptibility among diabetics.
AIM 02Evaluate the impact of diabetes on cerebrovascular integrity during ischemic events.
AIM 03Assess the therapeutic potential of targeting O-GlcNAcylation for stroke recovery.
AIM 04Measure neurovascular injury and functional recovery post-stroke in diabetic models.
AIM 05Determine the differential roles of OGT and OGA in cerebrovascular health.
Skills the Lab Values
cell cultureanimal modelsthromboembolismimmunohistochemistryglucose measurementsbehavioral assessmentsWestern blottinggene expression analysisproteomicsmicroscopy
Output against the department
Publications151top 45% of dept.465th of 1,033
this lab
most publishedleast published
Citations2.6kbottom 19% of dept.841st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.