University of Oregon · BiochemistryCell Division and Cytoskeleton Unit
Bruce A Bowerman · Eugene, Oregon
Research Focus
Dr. Bruce Bowerman’s lab at the University of Oregon focuses on studying how cells divide, particularly in the early embryos of a small worm called C. elegans. By using advanced techniques like live cell imaging and CRISPR technology, the lab investigates the role of the cytoskeleton during cell division, which has implications for understanding fertility and cancer. This research helps to uncover general principles of how cells function in all animals.
C. eleganscytoskeletoncell divisionCRISPRlive cell imagingmeiosismitosisatomic force microscopyoocyte cortexfertility
Research Aims
4AIM 01Investigate the regulation of the cytoskeleton during cell division in C. elegans embryos.
AIM 02Explore mechanisms of acentrosomal spindle assembly and their significance for meiosis and mitosis.
AIM 03Examine the role of the oocyte cortex in microtubule function and animal cell division.
AIM 04Apply atomic force microscopy to study the physical properties of animal cell cortices.
Skills the Lab Values
CRISPR/Cas9 gene editinglive cell imagingfluorescent protein taggingmolecular genetics techniquesatomic force microscopygenetic mutation analysiscell culture of nematodeshigh-resolution light microscopytemperature-sensitive genetic mutationsauxin-mediated protein degradation
Output against the department
Publications180top 47% of dept.190th of 402
this lab
most publishedleast published
Citations13ktop 38% of dept.154th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.