WFUWake Forest University · Biology
Deep Neurodegeneration Lab
Gagan Deep · Winston-Salem, North Carolina
Research Focus
Dr. Gagan Deep's lab focuses on understanding Alzheimer's disease and related dementias through innovative methods like 'liquid biopsies'. They investigate how a special diet known as the Modified Mediterranean-Ketogenic Diet impacts brain function and biomarkers in individuals with mild cognitive impairment. Their research also looks at how different types of brain cells communicate and contribute to the progression of dementia, especially considering diverse populations.
Alzheimer's Diseasemild cognitive impairmentliquid biopsiesModified Mediterranean-Ketogenic Dietexosomesneurodegenerationvascular factorsbiomarkersmulti-ethnic studiesdietary intervention
Research Aims
3AIM 01Investigate the effects of the Modified Mediterranean-Ketogenic Diet on biomarkers related to Alzheimer's disease using brain-derived exosomes.
AIM 02Characterize exosomes from different brain cells to understand their role in neurodegeneration.
AIM 03Evaluate the relationship between vascular health and Alzheimer’s disease in diverse populations.
Skills the Lab Values
cell cultureexosome isolationbiomarker analysisMRI imagingPET imagingcognitive testingdata analysisbiofluid collectionmolecular characterizationstatistical software
Output against the department
Publications212top 30% of dept.314th of 1,033
this lab
most publishedleast published
Citations7.7ktop 48% of dept.497th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.