University of North Carolina at Chapel Hill · PharmacologyNguyen Lab
Juliane Nguyen · Chapel Hill, North Carolina
Research Focus
Dr. Juliane Nguyen's research lab focuses on developing innovative therapies using engineered probiotics and extracellular vesicles to improve treatments for chronic diseases like inflammatory bowel disease and ischemic heart disease. The lab aims to create safer, more effective medicine that targets the root causes of these conditions, potentially enhancing patient recovery and quality of life. By integrating advanced technologies in pharmacology and biomedical engineering, Dr. Nguyen's team seeks to bridge the gap between laboratory research and clinical application.
Inflammatory Bowel DiseaseProbioticsCardiac RepairExtracellular VesiclesTargeted TherapeuticsGastrointestinal HealthHeart Attack RecoveryMicrobiome Modulation
Research Aims
5AIM 01Develop engineered probiotic yeast to treat inflammatory bowel diseases.
AIM 02Optimize delivery strategies for extracellular vesicles to enhance cardiac repair.
AIM 03Evaluate therapeutic potential of probiotics in altering gut microbiota.
AIM 04Assess pharmacokinetics and biodistribution of targeted therapies in mouse models.
AIM 05Investigate effectiveness of extracellular vesicles in swine models of heart injury.
Skills the Lab Values
Cell CultureAnimal ModelsFlow CytometryPCRBiochemical AssaysImmunohistochemistryBiodistribution AnalysisComputational ModelingNanoparticle Synthesis
Output against the department
Publications108bottom 29% of dept.329th of 462
this lab
most publishedleast published
Citations4.2kbottom 31% of dept.317th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.