Icahn School of Medicine at Mount Sinai · Microbiology & ImmunologyEbola Virus Dynamics Lab
Christopher F Basler · New York, New York
Research Focus
Dr. Christopher F. Basler's lab at the Icahn School of Medicine investigates how the Ebola virus assembles and infects cells, focusing on a key protein called VP24. This protein not only helps package viral components but also interferes with the body's immune response. By understanding VP24's functions, the lab aims to uncover new strategies for preventing and treating Ebola infections.
Ebola virusviral assemblyVP24 proteinimmune responsenuclear trafficking
Research Aims
5AIM 01Explore how the VP24 protein aids in the assembly of Ebola viruses.
AIM 02Determine the role of VP24 in blocking immune responses.
AIM 03Identify the molecular mechanisms behind VP24's interaction with transport proteins.
AIM 04Investigate the nuclear export and import functions of VP24.
AIM 05Uncover how VP24 influences the trafficking of viral nucleocapsids.
Skills the Lab Values
cell cultureviral infection assaysmolecular cloningprotein purificationflow cytometry
Output against the department
Publications248top 23% of dept.112th of 486
this lab
most publishedleast published
Citations24ktop 15% of dept.75th of 486
this lab
most citedleast cited
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