University of Minnesota-Twin Cities · Microbiology & ImmunologyFife Lab
Brian T Fife · Minneapolis, Minnesota
Research Focus
Brian T. Fife's research lab at the University of Minnesota focuses on understanding type 1 diabetes, an autoimmune condition causing the destruction of insulin-producing cells. The lab studies how a diverse microbial environment can influence immune responses, potentially protecting against or triggering diabetes. Additionally, the lab is innovating ways to engineer regulatory T cells (Tregs) to specifically target and suppress the autoimmune response associated with this disease, aiming to develop effective therapies.
autoimmune diabetesregulatory T cellsmicrobial environmentT cell engineeringimmunotherapytype 1 diabeteschimeric antigen receptorβ-cell protectionimmune tolerance
Research Aims
3AIM 01Investigate how different microbial exposures affect immune responses in diabetes models.
AIM 02Understand the mechanisms through which engineered Tregs can protect pancreatic beta cells.
AIM 03Develop therapies that manipulate Treg function to treat or prevent type 1 diabetes.
Skills the Lab Values
cell cultureanimal modelsflow cytometrygene expression analysisPCRCrispr/Cas9antibody engineeringin vivo studiesimmunological assays
Output against the department
Publications123bottom 47% of dept.260th of 486
this lab
most publishedleast published
Citations9.1ktop 40% of dept.195th of 486
this lab
most citedleast cited
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