UTMThe University of Texas MD Anderson Cancer Center · Microbiology & Immunology
T Cell Genomics and Immunotherapy Lab
Liuqing Yang · Houston, Texas
Research Focus
Dr. Liuqing Yang's lab studies the intricate structures of DNA in T cells, particularly how they change in response to cancer, specifically renal medullary carcinoma (RMC). The lab uses advanced techniques to explore how genetic structures influence immune responses and the aggressive nature of cancer, especially in patients with sickle cell disease. Their research aims to improve cancer treatments by enhancing our understanding of the immune system's role in fighting tumors.
T Cell BiologyFerroptosisChromatin StructureCancer ImmunotherapyRenal CarcinomaSickle Cell DiseaseGenome ArchitectureImmune Microenvironment
Research Aims
4AIM 01Investigate the impact of altered chromatin architecture on T cells in renal medullary carcinoma.
AIM 02Understand the molecular connection between sickle cell disease and renal carcinoma.
AIM 03Explore the mechanisms of ferroptosis in CD8+ T cells from sickle cell disease patients.
AIM 04Assess the therapeutic potential of immune checkpoint inhibitors for treating renal medullary carcinoma.
Skills the Lab Values
Hi-C TechniqueChromatin AnalysisT Cell IsolationCell CultureGenomic SequencingFlow CytometryData InterpretationImmunohistochemistry
Output against the department
Publications618top 4% of dept.18th of 486
this lab
most publishedleast published
Citations15ktop 26% of dept.128th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.