Washington University in St Louis · Microbiology & ImmunologyDing Lab
Siyuan Ding · Saint Louis, Missouri
Research Focus
Dr. Siyuan Ding's research lab focuses on understanding how rotaviruses, a leading cause of severe diarrhea in infants and children, spread between cells and evade the immune system. By investigating specific viral proteins' interactions with host cell components, the lab aims to uncover new ways to improve vaccines and develop effective antiviral treatments against rotavirus infections. Their work combines advanced techniques from microbiology and immunology to address significant health challenges, especially in vulnerable populations.
rotavirusimmunologyviral pathogenesiscell-to-cell transmissionantiviral therapeutics
Research Aims
5AIM 01Investigate the role of VP4 protein in rotavirus cell-to-cell transmission
AIM 02Characterize the interactions between rotavirus proteins and host cell components
AIM 03Study the immune evasion mechanisms of NSP6
AIM 04Develop new vaccine candidates based on NSP6-deletion rotavirus
AIM 05Evaluate antiviral strategies targeting viral-host interactions
Skills the Lab Values
PCRcell cultureCRISPRmouse modelsRNA sequencingflow cytometrymass spectrometryimmunohistochemistrybiochemical assays2-photon microscopy
Output against the department
Publications120bottom 46% of dept.264th of 486
this lab
most publishedleast published
Citations5.6kbottom 42% of dept.282nd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.