Drexel University · PharmacologyFatatis Oncology Lab
Alessandro Fatatis · Philadelphia, Pennsylvania
Research Focus
Dr. Alessandro Fatatis's lab at Drexel University focuses on understanding how certain cancer cells thrive in the harsh environment of metastatic prostate cancer, especially when traditional therapies targeting the Androgen Receptor fail. They explore the role of Interleukin-1beta, a signaling molecule that may help cancer cells survive and spread in bone tissue. Through their research, they aim to uncover new treatment strategies that could complement existing therapies and combat advanced prostate cancer more effectively.
prostate cancerandrogen receptorcastration-resistantmetastatic diseaseInterleukin-1bone microenvironmenttherapeutic resistancecytokinestranscriptional regulation
Research Aims
3AIM 01Define IL-1's role in aiding cancer cell survival during androgen deprivation therapy.
AIM 02Investigate how bone stroma interacts with IL-1 to regulate androgen receptor-positive cancer cells.
AIM 03Elucidate mechanisms of IL-1 regulation by the androgen receptor.
Skills the Lab Values
cell cultureanimal modelsmolecular biologyPCRWestern blotimmunohistochemistryflow cytometryRNA sequencingdata analysistissue sample processing
Output against the department
Publications210top 41% of dept.190th of 462
this lab
most publishedleast published
Citations4.3kbottom 32% of dept.315th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.