University of Michigan-Ann Arbor · BiologyLieberman Lab
Andrew P Lieberman · Ann Arbor, Michigan
Research Focus
Dr. Andrew P. Lieberman's lab at the University of Michigan focuses on developing therapies for Niemann-Pick Type C disease, a serious genetic disorder that causes neurodegeneration. The research aims to understand the mechanisms behind the disease, particularly the role of cholesterol in brain cells and how novel treatments can alleviate symptoms. Students in this lab will work on innovative approaches to drug development, studying both neuron and oligodendrocyte cell functions in the context of the disease.
Niemann-Pick Disease Type Cneurodegenerationcholesterol traffickingCNS diseasesoligodendrocytesdrug developmentsynthetic HDLproteostasislipid metabolism
Research Aims
5AIM 01Define critical targets in CNS disease pathogenesis to aid drug development.
AIM 02Investigate how synthetic HDL nanoparticles can rescue lipid storage in neurons.
AIM 03Explore the role of oligodendrocyte lineage cells in the neuropathology of NPC.
AIM 04Test therapeutic strategies to correct misfolding of mutant NPC1 protein.
AIM 05Establish the pathogenic mechanisms underlying Niemann-Pick Type C disease.
Skills the Lab Values
cell culturemouse modelsbiochemical assayshistological analysisgenetic analysisprotein expressionnanoparticle formulationWestern blotRNA sequencing
Output against the department
Publications156top 43% of dept.448th of 1,033
this lab
most publishedleast published
Citations21ktop 18% of dept.191st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.