University of Vermont · PharmacologyHarraz Vascular Lab
Osama F Harraz · Burlington, Vermont
Research Focus
Dr. Osama F Harraz's lab at the University of Vermont focuses on understanding how blood flow to the brain is regulated and how that process is affected in conditions like hypertension. They study a protein called Piezo1, which acts as a sensor in blood vessel cells, enabling them to respond to changes in blood flow. By examining how this protein functions in different scenarios, the lab aims to identify new strategies for treating cardiovascular diseases that impact brain health.
blood flow regulationhypertensionPiezo1cerebral blood flowvascular biologyneurovascular couplingcalcium signalingendothelial cellscardiovascular diseasebrain health
Research Aims
3AIM 01Investigate the role of Piezo1 in regulating blood flow at the capillary level in the brain.
AIM 02Determine how Piezo1 contributes to the larger scale regulation of cerebral blood flow during hyperemia.
AIM 03Examine the effects of hypertension on Piezo1 function and its implications for blood flow regulation.
Skills the Lab Values
fluorescence imaginggenetic engineeringmouse modelspharmacological approacheslaser Doppler flowmetrynear-infrared imagingcalcium imagingdata analysismicroscopyexperimental design
Output against the department
Publications71bottom 15% of dept.393rd of 462
this lab
most publishedleast published
Citations1.7kbottom 10% of dept.417th of 462
this lab
most citedleast cited
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